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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Pitolisant</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable infobox float-right" id="Vorlage_Infobox_Chemikalie" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Chemikalie">
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Strukturformel
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<td colspan="2" class="hintergrundfarbe-basis skin-invert-image" style="text-align:center;"><span typeof="mw:File"></span>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Allgemeines
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<td style="width:33%;"><a href="Internationaler_Freiname" title="Internationaler Freiname">Freiname</a>
</td>
<td>Pitolisant
</td></tr>
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<td>Andere Namen
</td>
<td>
<ul><li>1-(3-(3-(4-Chlorphenyl)propoxy)propyl)piperidin <small>(<a href="IUPAC-Nomenklatur" class="mw-redirect" title="IUPAC-Nomenklatur">IUPAC</a>)</small></li>
<li>Tiprolisant <small>(<a href="United_States_Adopted_Names_Council" title="United States Adopted Names Council">USAN</a>)</small></li>
<li>BF 2649</li>
<li>Ozawade</li></ul>
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<tr>
<td><a href="Summenformel" title="Summenformel">Summenformel</a>
</td>
<td>C<sub>17</sub>H<sub>26</sub>ClNO
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<td>Kurzbeschreibung
</td>
<td>
<p>weißer Feststoff<sup id="cite_ref-tocris_1-0" class="reference"><a href="#cite_note-tocris-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</p>
</td></tr>
<tr>
<th colspan="2" style="background:#FFDEAD; color:#202122;">Externe Identifikatoren/Datenbanken
</th></tr>
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<td colspan="2" style="padding:0;">
<table class="mw-collapsible mw-collapsed wikitable" data-expandtext="+" data-collapsetext="−" style="border-top:none; margin:-1px; width:calc(100% + 2px);">
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<td style="width:33%;"><a href="CAS-Nummer" title="CAS-Nummer">CAS-Nummer</a>
</td>
<td>
<ul><li><span title="Untervorlage eingebunden: CASRN"></span><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=362665-56-3">362665-56-3</a><span class="editoronly" style="display:none;"></span> (Pitolisant)</li>
<li><span title="Untervorlage eingebunden: CASRN"></span><span class="KeinCASLink" title="CAS-Nummer ohne Common-Chemistry-Eintrag">903576-44-3</span><span class="editoronly" style="display:none;"></span> (Hydrochlorid)</li></ul>
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<td style="background:#FFDEAD; color:#202122; border-top:1px solid #FFDEAD; padding:0.2em 0; vertical-align:bottom; width:5%;">
</td></tr>
<tr>
<td><a href="PubChem" title="PubChem">PubChem</a>
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/9948102">9948102</a>
</td></tr>
<tr>
<td><a href="ChemSpider" title="ChemSpider">ChemSpider</a>
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.8123714.html">8123714</a>
</td></tr>
<tr>
<td><a href="DrugBank" title="DrugBank">DrugBank</a>
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB11642">DB11642</a>
</td></tr>
<tr>
<td style="border-right:1px solid #a2a9b1;"><a href="Wikidata" title="Wikidata">Wikidata</a>
</td>
<td colspan="2"><a href="https://www.wikidata.org/wiki/Q426044" class="extiw external" title="d:Q426044">Q426044</a>
</td></tr></tbody></table>
</td></tr>
<tr>
<th colspan="2" style="background:#FFDEAD; color:#202122;">Arzneistoffangaben
</th></tr>
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<td><a href="Anatomisch-Therapeutisch-Chemisches_Klassifikationssystem" title="Anatomisch-Therapeutisch-Chemisches Klassifikationssystem">ATC-Code</a>
</td>
<td>
<p>N07<a rel="nofollow" class="external text" href="https://atcddd.fhi.no/atc_ddd_index/?code=N07XX11">XX11</a><span class="editoronly" style="display:none;"></span>
</p>
</td></tr>
<tr>
<td><a href="Wirkstoffklasse" title="Wirkstoffklasse">Wirkstoffklasse</a>
</td>
<td>
<p><a href="Antihistaminikum" title="Antihistaminikum">Antihistaminikum</a>
</p>
</td></tr>
<tr>
<td><a href="Pharmakodynamik#Wirkmechanismus" title="Pharmakodynamik">Wirkmechanismus</a>
</td>
<td>
<p>Histamin-H<sub>3</sub>-Rezeptorantagonist
</p>
</td></tr>
<tr>
<th colspan="2" style="background:#FFDEAD; color:#202122;">Eigenschaften
</th></tr>
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<td><a href="Molare_Masse" title="Molare Masse">Molare Masse</a>
</td>
<td>295,9 <a href="Gramm" title="Gramm">g</a>·<a href="Mol" title="Mol">mol</a><sup>−1</sup>
</td></tr>
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<td><a href="L%C3%B6slichkeit" title="Löslichkeit">Löslichkeit</a>
</td>
<td>
<p>Das Hydrochlorid ist löslich in Wasser<sup id="cite_ref-tocris_1-1" class="reference"><a href="#cite_note-tocris-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</p>
</td></tr>
<tr>
<th colspan="2" style="background:#FFDEAD; color:#202122;">Sicherheitshinweise
</th></tr>
<tr>
<td colspan="2">
<table cellspacing="0" cellpadding="2" style="width:100%;">
<tbody><tr>
<td colspan="2" style="border-bottom:1px #A7A7A7 dashed; text-align:center;">Bitte die Befreiung von der Kennzeichnungspflicht für Arzneimittel, Medizinprodukte, Kosmetika, Lebensmittel und Futtermittel beachten
</td></tr>
<tr>
<td colspan="2" style="text-align:center"><b><a href="Global_harmonisiertes_System_zur_Einstufung_und_Kennzeichnung_von_Chemikalien" title="Global harmonisiertes System zur Einstufung und Kennzeichnung von Chemikalien">GHS-Gefahrstoffkennzeichnung</a></b><sup id="cite_ref-tocris_1-2" class="reference"><a href="#cite_note-tocris-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
<p>Hydrochlorid
</p>
<table class="hintergrundfarbe-neutral" style="text-align:center; margin-left:auto; margin-right:auto; display:flex; justify-content:center;">
<tbody><tr>
<td><i>keine GHS-Piktogramme</i>
</td></tr></tbody></table>
<p>
</p>
</td></tr>
<tr>
<td rowspan="2" width="33%" style="border-top:1px #A7A7A7 dashed; border-right:1px #A7A7A7 dashed;"><a href="H-_und_P-S%C3%A4tze" title="H- und P-Sätze">H- und P-Sätze</a>
</td>
<td style="border-top:1px #A7A7A7 dashed;">H: <span title="Untervorlage eingebunden: H-Sätze"></span><i>keine H-Sätze</i>
</td></tr>
<tr>
<td style="border-top:1px #A7A7A7 dashed;">P: <span title="Untervorlage eingebunden: P-Sätze"></span><i>keine P-Sätze</i><sup id="cite_ref-tocris_1-3" class="reference"><a href="#cite_note-tocris-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</td></tr>
</tbody></table>
</td></tr>
<tr>
<td colspan="2" style="background:#FFDEAD; color:#202122; font-size:80%; text-align:center; line-height:150%; padding:.25em;">Wenn nicht anders vermerkt, gelten die angegebenen Daten bei <a href="Standardbedingungen" title="Standardbedingungen">Standardbedingungen</a> (0 °C, 1000 hPa).
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>Pitolisant</b> ist ein <a href="Arzneistoff" title="Arzneistoff">Arzneistoff</a> aus der Gruppe der H<sub>3</sub>-<a href="Antihistaminika" class="mw-redirect" title="Antihistaminika">Antihistaminika</a>. Er wurde von <a href="Walter_Schunack" title="Walter Schunack">Walter Schunack</a> und Jean-Charles Schwartz in Zusammenarbeit mit dem französischen Pharmaunternehmen Bioprojet entwickelt.
</p>
<div class="mw-heading mw-heading2"><h2 id="Anwendungsgebiete">Anwendungsgebiete</h2></div>
<p>Für eine mögliche Anwendung zur Behandlung der exzessiven Tagschläfrigkeit (EDS) bei <a href="Narkolepsie" title="Narkolepsie">Narkolepsie</a> wurde Pitolisant der Status eines <a href="Orphan-Arzneimittel" title="Orphan-Arzneimittel">Orphan-Arzneimittels</a> zuerkannt. In dieser Indikation wurde es im März 2016 unter dem Fertigarzneimittelnamen <i>Wakix</i> in der EU zugelassen. Weitere potenzielle Anwendungsgebiete dieses Arzneistoffs, werden derzeit in den Phasen II und III der klinischen Forschung erprobt. Dazu gehören u. a. die Verbesserung der kognitiven Fähigkeiten bei <a href="Schizophrenie" title="Schizophrenie">Schizophrenie</a>-Patienten<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>, die Behandlung der exzessiven Tagschläfrigkeit beim <a href="Schlafapnoe-Syndrom" title="Schlafapnoe-Syndrom">Schlafapnoe-Syndrom</a><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> und der <a href="Parkinson-Krankheit" title="Parkinson-Krankheit">Parkinson-Krankheit</a><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> sowie der Fotosensibilität bei genetischen (idiopathischen) Epilepsien.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>
</p><p>Eine Dosisanpassung ist bei fortgeschrittener <a href="Leberinsuffizienz" class="mw-redirect" title="Leberinsuffizienz">Leberinsuffizienz</a> bzw. bei fortgeschrittener <a href="Niereninsuffizienz" title="Niereninsuffizienz">Niereninsuffizienz</a> erforderlich. Zudem sind Interaktionen mit Medikamenten, welche auf das <a href="CYP3A4" class="mw-redirect" title="CYP3A4">CYP3A4</a>- bzw. das <a href="CYP2D6" class="mw-redirect" title="CYP2D6">CYP2D6</a>-System wirken, zu beachten.<sup id="cite_ref-wakix_8-0" class="reference"><a href="#cite_note-wakix-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Wirkmechanismus">Wirkmechanismus</h2></div>
<p>Pitolisant vermittelt seine Wirkung als selektiver Histamin 3 (H3)-Rezeptorantagonist / <a href="Inverser_Agonist" title="Inverser Agonist">inverser Agonist</a> am <a href="Histamin-H3-Rezeptor" title="Histamin-H3-Rezeptor">Histamin-H<sub>3</sub>-Rezeptor</a>, der insbesondere <a href="Pr%C3%A4synaptisch" class="mw-redirect" title="Präsynaptisch">präsynaptisch</a> auf <a href="Nervenzelle" title="Nervenzelle">Nervenzellen</a> des <a href="Zentralnervensystem" title="Zentralnervensystem">Zentralnervensystems</a> zu finden ist. Die <a href="Affinit%C3%A4t_(Biochemie)" title="Affinität (Biochemie)">Affinität</a> von Pitolisant zu diesem <a href="Rezeptor_(Biochemie)" title="Rezeptor (Biochemie)">Rezeptor</a> liegt im niedrigen nanomolaren Bereich.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup>
</p><p>Pitolisant wirkt – anders als andere Narkolepsie-Medikamente – nicht als Stimulans. Aus diesem Grund ist eine vollständige Wirkung erst nach mehreren Wochen zu erwarten.<sup id="cite_ref-wakix_8-1" class="reference"><a href="#cite_note-wakix-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>
<ul><li>Holger Stark: <cite style="font-style:italic">Neue Generationen von Antihistaminika</cite>. In: <cite style="font-style:italic">Pharmazeutische Zeitung</cite>. <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>32</span>, 2011 (<a rel="nofollow" class="external text" href="https://www.pharmazeutische-zeitung.de/index.php?id=38910">pharmazeutische-zeitung.de</a>).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Pitolisant&rft.atitle=Neue+Generationen+von+Antihistaminika&rft.au=Holger+Stark&rft.date=2011&rft.genre=journal&rft.issue=32&rft.jtitle=Pharmazeutische+Zeitung" style="display:none"> </span></li>
<li>Jean-Charles Schwartz: <cite class="lang" lang="en" dir="auto" style="font-style:italic">The histamine H3 receptor: from discovery to clinical trials with pitolisant</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Br. J. Pharmacol.</cite> <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>163</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, 2011, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>713–721</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1111/j.1476-5381.2011.01286.x">10.1111/j.1476-5381.2011.01286.x</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/21615387?dopt=Abstract">PMID 21615387</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111674/">PMC 3111674</a> (freier Volltext) – (englisch, <a rel="nofollow" class="external text" href="https://www.pharmazeutische-zeitung.de/index.php?id=38910">pharmazeutische-zeitung.de</a>).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Pitolisant&rft.atitle=The+histamine+H3+receptor%3A+from+discovery+to+clinical+trials+with+pitolisant&rft.au=Jean-Charles+Schwartz&rft.date=2011&rft.doi=10.1111%2Fj.1476-5381.2011.01286.x&rft.genre=journal&rft.issue=4&rft.jtitle=Br.+J.+Pharmacol.&rft.pages=713-721&rft.pmc=3111674&rft.pmid=21615387&rft.volume=163" style="display:none"> </span></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Weblinks">Weblinks</h2></div>
<div class="sisterproject" style="margin:0.1em 0 0 0;"><div class="noresize noviewer" style="display:inline-block; line-height:10px; min-width:1.6em; text-align:center;" aria-hidden="true" role="presentation"><span class="mw-default-size" typeof="mw:File"><span title="Commons"></span></span></div><b><span class=""><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Pitolisant?uselang=de"><span lang="en">Commons</span>: Pitolisant</a></span></b> – Sammlung von Bildern</div>
<ul><li><a href="European_Public_Assessment_Report" title="European Public Assessment Report">Öffentlicher Beurteilungsbericht</a> (EPAR) der <a href="Europ%C3%A4ische_Arzneimittel-Agentur" title="Europäische Arzneimittel-Agentur">Europäischen Arzneimittel-Agentur</a> (EMA) zu: <a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/search/search/field_ema_web_categories%253Aname_field/Human/ema_group_types/ema_medicine?search_api_views_fulltext=Pitolisant">Pitolisant</a></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-tocris-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-tocris_1-0">a</a></sup> <sup><a href="#cite_ref-tocris_1-1">b</a></sup> <sup><a href="#cite_ref-tocris_1-2">c</a></sup> <sup><a href="#cite_ref-tocris_1-3">d</a></sup></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://www.tocris.com/literature/3743_sds.pdf?1350048100"><i>MSDS BF 2649 hydrochloride.</i></a> (PDF) Tocris,<span class="Abrufdatum"> abgerufen am 27. Dezember 2019</span> (englisch).</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3APitolisant&rft.title=MSDS+BF+2649+hydrochloride&rft.description=MSDS+BF+2649+hydrochloride&rft.identifier=https%3A%2F%2Fwww.tocris.com%2Fliterature%2F3743_sds.pdf%3F1350048100&rft.publisher=Tocris&rft.language=en"> </span></span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/show/study/NCT00690274"><i>Study to Demonstrate Cognitive Enhancing Effects of BF2.649.</i></a><span class="Abrufdatum"> Abgerufen am 11. Oktober 2012</span> (englisch).</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3APitolisant&rft.title=Study+to+Demonstrate+Cognitive+Enhancing+Effects+of+BF2.649&rft.description=Study+to+Demonstrate+Cognitive+Enhancing+Effects+of+BF2.649&rft.identifier=http%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2Fstudy%2FNCT00690274&rft.language=en"> </span></span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/show/NCT01072968"><i>BF2.649 in Patients With OSA, Still Complaining of EDS and Refusing to be Treated by CPAP. (HAROSA2).</i></a><span class="Abrufdatum"> Abgerufen am 11. Oktober 2012</span> (englisch).</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3APitolisant&rft.title=BF2.649+in+Patients+With+OSA%2C+Still+Complaining+of+EDS+and+Refusing+to+be+Treated+by+CPAP.+%28HAROSA2%29&rft.description=BF2.649+in+Patients+With+OSA%2C+Still+Complaining+of+EDS+and+Refusing+to+be+Treated+by+CPAP.+%28HAROSA2%29&rft.identifier=http%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT01072968&rft.language=en"> </span></span>
</li>
<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/show/NCT01071876"><i>BF2.649 in Patients With OSA and Treated by CPAP But Still Complaining of EDS (HAROSA1).</i></a><span class="Abrufdatum"> Abgerufen am 11. Oktober 2012</span> (englisch).</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3APitolisant&rft.title=BF2.649+in+Patients+With+OSA+and+Treated+by+CPAP+But+Still+Complaining+of+EDS+%28HAROSA1%29&rft.description=BF2.649+in+Patients+With+OSA+and+Treated+by+CPAP+But+Still+Complaining+of+EDS+%28HAROSA1%29&rft.identifier=http%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT01071876&rft.language=en"> </span></span>
</li>
<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/show/NCT01036139"><i>Efficacy and Safety of BF2.649 in Excessive Daytime Sleepiness (EDS) in Parkinson’s Disease (HARPS1).</i></a><span class="Abrufdatum"> Abgerufen am 11. Oktober 2012</span> (englisch).</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3APitolisant&rft.title=Efficacy+and+Safety+of+BF2.649+in+Excessive+Daytime+Sleepiness+%28EDS%29+in+Parkinson%E2%80%99s+Disease+%28HARPS1%29&rft.description=Efficacy+and+Safety+of+BF2.649+in+Excessive+Daytime+Sleepiness+%28EDS%29+in+Parkinson%E2%80%99s+Disease+%28HARPS1%29&rft.identifier=http%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT01036139&rft.language=en"> </span></span>
</li>
<li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/show/NCT01066442"><i>Efficacy and Safety of BF2.649 in Excessive Daytime Sleepiness (EDS) in Parkinson’s Disease (HARPS2).</i></a><span class="Abrufdatum"> Abgerufen am 11. Oktober 2012</span> (englisch).</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3APitolisant&rft.title=Efficacy+and+Safety+of+BF2.649+in+Excessive+Daytime+Sleepiness+%28EDS%29+in+Parkinson%E2%80%99s+Disease+%28HARPS2%29&rft.description=Efficacy+and+Safety+of+BF2.649+in+Excessive+Daytime+Sleepiness+%28EDS%29+in+Parkinson%E2%80%99s+Disease+%28HARPS2%29&rft.identifier=http%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT01066442&rft.language=en"> </span></span>
</li>
<li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text">D. Kasteleijn-Nolst Trenité, D. Parain, P. Genton et al.: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: Dose-dependent effects in the human photosensitivity model</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Epilepsy Behav</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>28</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 2013, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>66–70</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.yebeh.2013.03.018">10.1016/j.yebeh.2013.03.018</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/23665640?dopt=Abstract">PMID 23665640</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Pitolisant&rft.atitle=Efficacy+of+the+histamine+3+receptor+%28H3R%29+antagonist+pitolisant+%28formerly+known+as+tiprolisant%3B+BF2.649%29+in+epilepsy%3A+Dose-dependent+effects+in+the+human+photosensitivity+model&rft.au=D.+Kasteleijn-Nolst+Trenit%C3%A9%2C+D.+Parain%2C+P.+Genton+et+al.&rft.date=2013&rft.doi=10.1016%2Fj.yebeh.2013.03.018&rft.genre=journal&rft.issue=1&rft.jtitle=Epilepsy+Behav&rft.pages=66-70&rft.pmid=23665640&rft.volume=28" style="display:none"> </span></span>
</li>
<li id="cite_note-wakix-8"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-wakix_8-0">a</a></sup> <sup><a href="#cite_ref-wakix_8-1">b</a></sup></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://wakix.com/pdf/wakix-tablets-pi.pdf"><i>Wakix.</i></a> (PDF)<span class="Abrufdatum"> Abgerufen am 11. Juli 2024</span> (englisch).</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3APitolisant&rft.title=Wakix&rft.description=Wakix&rft.identifier=https%3A%2F%2Fwakix.com%2Fpdf%2Fwakix-tablets-pi.pdf&rft.language=en"> </span></span>
</li>
<li id="cite_note-9"><span class="mw-cite-backlink"><a href="#cite_ref-9">↑</a></span> <span class="reference-text">Jean-Charles Schwartz: <cite class="lang" lang="en" dir="auto" style="font-style:italic">The histamine H3 receptor: from discovery to clinical trials with pitolisant</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Br. J. Pharmacol.</cite> <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>163</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, 2011, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>713–721</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1111/j.1476-5381.2011.01286.x">10.1111/j.1476-5381.2011.01286.x</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/21615387?dopt=Abstract">PMID 21615387</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111674/">PMC 3111674</a> (freier Volltext) – (englisch, <a rel="nofollow" class="external text" href="https://www.pharmazeutische-zeitung.de/index.php?id=38910">pharmazeutische-zeitung.de</a>).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Pitolisant&rft.atitle=The+histamine+H3+receptor%3A+from+discovery+to+clinical+trials+with+pitolisant&rft.au=Jean-Charles+Schwartz&rft.date=2011&rft.doi=10.1111%2Fj.1476-5381.2011.01286.x&rft.genre=journal&rft.issue=4&rft.jtitle=Br.+J.+Pharmacol.&rft.pages=713-721&rft.pmc=3111674&rft.pmid=21615387&rft.volume=163" style="display:none"> </span></span>
</li>
</ol>
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